DNA double strand breaks lead to de novo transcription and translation of damage-induced long RNAs in planta doi.org/10.1101/2022.0… pic.twitter.com/52mkOJXG2l
In case anyone wants to use our models for meiotic patterning - the code is available at github.com/jfozard/HEI10 and github.com/jfozard/hei10_…
Check out the latest from the lab, looking at triple-helical H-DNA in mouse. This was carried out entirely by Kaku Maekawa from Kyoto University @KyotoU_News starting when he was an undergrad intern working here with Shintaro Yamada pnas.org/eprint/PQTX8Z9…
@arjunrajlab I've been a huge fan of Big Rose Web Design (founded by a former bench scientist), who specialize in making online lab databases for strains, plasmids, oligos, etc. Can upload plasmid maps and references and the search function works well. bigrosestudio.com
Our new paper with @PatrickSungLab on the formation of ssDNA loops during human DNA end resection is finally out in @NatureComms! Thank you to all collaborators and congratulations to Chaoyou and Sameer!!! Read the open access paper here: rdcu.be/cL93h
A simpler method to make double Holliday junction substrates for in vitro biochemistry. Reveals that chromatin suppresses nuclease cleavage of HJ, but not dissolution by Bloom syndrome complex. pnas.org/doi/10.1073/pn…
Happy to share our manuscript about how “Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations” which is now online in Mol Cell cell.com/molecular-cell…
Our preprint with @OwenDaviesLab and Willy Baarends is up on bioRxiv. Led by @JamesHCrichton and @JMDunce. There's some nice images of mammalian synaptonemal complex assembling in there (thanks @ESRIC_Imaging, @IgcImaging)... pic.twitter.com/x31ykmUvS7
11 Promises from a Manager: a 🧵 1. We’ll have a weekly 1:1. I’ll never cancel this meeting, but you can cancel it whenever you like. It’s your time.
It looks as if recombination-initiated SC forms via recombination-mediated central element protein recruitment in mammals biorxiv.org/content/10.110… and in yeast genesdev.cshlp.org/content/36/1-2… Cool!
When you submit your fastq files to a public repository, it seems GEO and ArrayExpress are the most popular ones. Which one do you choose? For me, it is always ArrayExpress. The reason is very simple and correct me if I'm wrong. 1/5
sciTwitter, what's the current best split-FP for protein-protein interactions in your opinion/experience?
I released a first version of a book on data visualization with R & ggplot2. Target audience = wet lab scientists. It's work in progress, so any feedback/suggestions/comments are appreciated!! #DataViz #Rstats joachimgoedhart.github.io/DataViz-protoc…
Below we discuss new insights into the potential role of chromatin as metabolite reservoir through histone modifications, possibly 'the elephant in the room' we need to learn to see: authors.elsevier.com/a/1euSS3S6GfIx…
Delighted to see PhD student Sam's and my review on meiotic gene conversion #Meiosis4eva for the Mendel anniversary issue @HeredityJournal @GenSocUK being published ahead of print today rdcu.be/cKRWj doi.org/10.1038/s41437…
Why are lncRNAs lowly expressed? How can they regulate their more abundant targets? Our paper published in @NatureSMB we explore how these features are balanced to ensure target specificity and robust gene regulation via a spatial amplification mechanism. nature.com/articles/s4159…
Ever wondered why the majority of mammalian gene promoters are embedded within CpG islands? Check out this beautiful work by @Amy_L_Hughes showing that a protein complex which binds to CGIs protects genes from premature transcription termination! biorxiv.org/content/10.110…
Latest from @BurgessLab: Our paper describing homolog pairing dynamics using live-cell imaging and polymer theory in collaboration with Andy Spakowitz @brunobeltran0 @Stanford @tacnewman @DanielElnatan @CahoonCori Dan Chu, Michael Paddy & James McGehee! pnas.org/doi/full/10.10…
Aujourd’hui, nous sommes le 16 mars. Très joyeux discord’anniversaire au serveur des doctorant-es créé il y’a déjà deux ans avec la merveilleuse @Eva_ptdmg. Il y’a tant de choses à dire sur cet espace, mais ce qui est certain c’est qu’il représente un héritage très important. 1/
Ever wondered whether it is possible to manipulate histone modifications at a specific locus and in a certain condition only? 🤔🌱✂️- Talented PhD student Vicky Oberkofler tried it out. Here's our article on inducible epigenome editing in Arabidopsis. doi.org/10.1093/plphys…
Our @Nature paper is now online: Paper: nature.com/articles/s4158… Code: github.com/1edv/evolution Data: bit.ly/EvolutionZenodo App: 1edv.github.io/evolution/ My most sincere thanks to Prof. Aviv Regev, @CarldeBoerPhD, @MIT, @broadinstitute and our collaborators pic.twitter.com/3b9wrQxqnw
DNA helicases are used in homologous recombination. We've used a gap repair assay originally designed by @mei_newt to determine how the BLM, FANCM, and HELQ helicases promote HR. Now published in Genes in a special issue co-edited by @JanLaRocquePhd. mdpi.com/journal/genes/…
Sister chromatids separate during anaphase in a three-stage program as directed by interaxis bridges pnas.org/doi/10.1073/pn…
Did you know chromosomal loops can repel one another? Did you know that Hi-C maps have a hidden signature that tells you the sizes of chromosomal loops? We came up with a theory that describes interphase chromosomes folded into loops! Check it out! biorxiv.org/content/10.110… pic.twitter.com/YNO3LHEQo8
In these dark times - when the homeland of my family is invaded by a dictator driven by nonsensical and deadly imperialistic ambitions - I would like to share the first paper of my PhD: "The evolution of recombination in self-fertilizing organisms", supervised by Denis Roze 1/5 twitter.com/biorxiv_evobio…
**new preprint** We found a new role for #condensin II complex in #checkpoint signalling during #drosophila male #meiosis. biorxiv.org/content/10.110…
#QuizAmeliorationDesPlantes QUIZ N°18 twitter.com/QADPlantes/sta…
#Quizameliorationdesplantes N°7 Contrôle de l'hybridation Pour produire des variétés hybrides, il faut disposer d’un système permettant de contrôler l’hybridation à grande échelle. La méthode utilisée est la castration mâle des fleurs. pic.twitter.com/cZ8ksw1CN7
#QuizAmeliorationDesPlantes N°2 [1/2] Domestication La domestication des plantes a débuté avec l'agriculture (-10 000) et a conduit à leur adaptation aux conditions de cultures imposées par l'homme pour répondre à ses besoins. Exemple de la transition téosinte > maïs pic.twitter.com/FdF7Vh0rdB
